Sildenafil belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. It works by relaxing the smooth muscles in the blood vessels, particularly in the penis, allowing for increased blood flow upon sexual stimulation. This mechanism makes Sildenafil highly effective in treating erectile dysfunction by helping men achieve and maintain an erection. Additionally, Sildenafil is used to treat pulmonary arterial hypertension by relaxing the blood vessels in the lungs, allowing blood to flow more easily. In the athletic community, Sildenafil is sometimes used to enhance blood flow and improve muscle pumps during intense physical activity.

For Erectile Dysfunction (ED):

Standard Dosage: 50 mg taken about 1 hour before sexual activity.

Can be adjusted to 25 mg (lower dose) or 100 mg (higher dose) based on individual response and tolerance.

Do not exceed 1 dose per day.

For Pulmonary Arterial Hypertension (PAH):

Standard Dosage: 20 mg taken 3 times daily, with doses spaced approximately 4–6 hours apart.

Dosage may vary as prescribed by a healthcare provider.

Sildenafil is typically taken orally in tablet form. The recommended starting dose for erectile dysfunction is 50 mg taken as needed about 30 to 60 minutes before sexual activity. The dose can be adjusted based on individual response and tolerance, with a maximum recommended dose of 100 mg and a minimum of 25 mg. For pulmonary arterial hypertension, the dosage is typically 20 mg taken three times a day, as prescribed by a healthcare provider.

It is important to take Sildenafil exactly as prescribed by a healthcare professional and not to exceed the recommended dose. Sildenafil can be taken with or without food, but a high-fat meal may delay its onset of action. It should not be taken more than once in a 24-hour period.

While Sildenafil is generally well-tolerated, some users may experience side effects:

Headache: headaches are one of the most common side effects of Sildenafil. These are usually mild and resolve on their own, but over-the-counter pain relievers can be used if needed.

Flushing: some users may experience flushing, a sensation of warmth and redness in the face, neck, or chest. This side effect is usually mild and temporary.

Dizziness and lightheadedness: sildenafil can cause dizziness or lightheadedness, particularly when standing up quickly. This is due to its blood pressure-lowering effects. Staying hydrated and avoiding sudden changes in position can help mitigate these symptoms.

Indigestion and upset stomach: sildenafil can cause gastrointestinal discomfort, including indigestion and an upset stomach. These symptoms are typically mild and can be managed with dietary adjustments or antacids.

Visual changes: rarely, Sildenafil can cause visual disturbances, such as blurred vision or a blue tint. If these symptoms occur, it is important to stop using the medication and consult a healthcare provider.

Nasal Congestion: some users may experience nasal congestion or a stuffy nose while taking Sildenafil. This side effect is usually mild and temporary.

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